Table 1.
Complex | EC50 complex-driven respiration (µM) | |||
---|---|---|---|---|
H | J | T | U | |
I | 118 ± 16.2 | 49.3 ± 5.55 (0.0390) | 69.0 ± 9.72 | 70.8 ± 9.47 |
II | 144 ± 12.1 | 63.1 ± 3.92 (0.0200) | 79.0 ± 8.96 | 110 ± 8.80 |
EC50 complex-driven respiration refers to the concentration of 2-hydroxyflutamide required to reduce complex I/II-driven respiration by 50%. Data are presented as mean ± SEM (p value) of n ≥ 6 independent experiments. P value indicates statistical significance compared with other haplogroups and is only shown if < 0.05.