Table 1.
Results of risk factors analysis of adverse reactions in TB patients.
| Variables | n | Rate of adverse reactions (per 1000 TB) | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
| OR(95%CI) | P-value | OR(95%CI) | P-value | |||
| Gender | ||||||
| Males | 1579 | 66.40 | Referent | Referent | ||
| Females | 916 | 38.52 | 1.12 (1.04–1.22) | 0.005 | 1.15 (1.06–1.25) | 0.001 |
| Age | ||||||
| 0~ | 126 | 5.30 | Referent | Referent | ||
| 20~ | 529 | 22.25 | 1.63 (1.34–1.98) | < 0.001 | 1.49 (1.21–1.84) | < 0.001 |
| 40~ | 756 | 31.79 | 2.37 (1.96–2.86) | < 0.001 | 2.20 (1.79–2.71) | < 0.001 |
| 60~ | 1084 | 45.58 | 3.99 (3.32–4.84) | < 0.001 | 3.69 (3.01–4.52) | < 0.001 |
| Nationality | ||||||
| Han | 1570 | 66.02 | Referent | Referent | ||
| Miao | 372 | 15.64 | 1.30 (1.17–1.46) | < 0.001 | 1.38 (1.23–1.54) | < 0.001 |
| Buyi | 154 | 6.48 | 0.82 (0.70–0.97) | 0.022 | 0.83 (0.70–0.98) | 0.031 |
| Yi | 51 | 2.14 | 0.75 (0.57–1.00) | 0.046 | 0.89 (0.67–1.18) | 0.412 |
| Dong | 152 | 6.39 | 1.75 (1.48–2.07) | < 0.001 | 1.88 (1.59–2.23) | < 0.001 |
| Tujia | 71 | 2.99 | 0.61 (0.48–0.77) | < 0.001 | 0.59 (0.47–0.75) | < 0.001 |
| Others | 125 | 5.26 | 1.49 (1.24–1.79) | < 0.001 | 1.59 (1.32–1.91) | < 0.001 |
| Occupation | ||||||
| Peasant workers | 2082 | 87.55 | Referent | Referent | ||
| Homemakers and unemployed persons | 153 | 6.43 | 1.26 (1.07–1.49) | 0.006 | 1.60 (1.35–1.90) | < 0.001 |
| Students | 91 | 3.83 | 0.43 (0.35–0.54) | < 0.001 | 0.73 (0.58–0.93) | 0.009 |
| Retired persons and cadres and staff | 94 | 3.95 | 1.94 (1.57–2.38) | < 0.001 | 1.68 (1.36–2.07) | < 0.001 |
| Others | 75 | 3.15 | 0.72 (0.57–0.90) | 0.005 | 0.91 (0.72–1.15) | 0.420 |
| Local registered residence | ||||||
| Yes | 2305 | 96.93 | Referent | Referent | ||
| No | 190 | 7.99 | 0.74 (0.64–0.86) | < 0.001 | 0.78 (0.66–0.90) | 0.001 |
| Source of patients | ||||||
| Clinical consultation | 1134 | 47.69 | Referent | Referent | ||
| Referral | 787 | 33.09 | 1.01 (0.92–1.11) | 0.862 | 0.97 (0.89–1.07) | 0.543 |
| Following up | 413 | 17.37 | 1.00 (0.90–1.12) | 0.956 | 1.02 (0.91–1.15) | 0.740 |
| Recommended for symptoms | 88 | 3.70 | 1.97(1.58–2.45) | < 0.001 | 2.17 (1.74–2.70) | 0.001 |
| Physical examinations | 41 | 1.72 | 0.73 (0.53–0.99) | 0.046 | 1.13 (0.82–1.55) | 0.460 |
| Others | 32 | 1.35 | 1.08 (0.76–1.54) | 0.677 | 1.16 (0.82–1.66) | 0.405 |
| Clinical classification | ||||||
| Type I | 0 | 0.00 | Referent | |||
| Type II | 51 | 2.14 | 0.00 | 0.996 | ||
| Type III | 2375 | 99.87 | 0.83 (0.39–1.75) | 0.619 | ||
| Type IV | 61 | 2.57 | 0.68 (0.34–1.36) | 0.275 | ||
| Type V | 8 | 0.34 | 0.66 (0.32–1.39) | 0.274 | ||
| Diagnosis | ||||||
| Etiological positivity | 723 | 30.40 | Referent | Referent | ||
| Etiological negative | 1709 | 71.87 | 1.14 (1.05–1.24) | 0.003 | 1.27 (1.17–1.41) | < 0.001 |
| Pure tuberculous pleurisy | 55 | 2.31 | 1.41 (1.07–1.85) | 0.015 | 1.81 (1.37–2.39) | < 0.001 |
| Others | 8 | 0.34 | 1.10 (0.54–2.21) | 0.800 | 1.52 (0.75–3.07) | 0.246 |
| Severe cases | ||||||
| Yes | 296 | 12.45 | Referent | Referent | ||
| No | 2199 | 92.47 | 1.20 (1.06–1.36) | 0.003 | 1.23 (1.09–1.39) | 0.001 |
| Therapeutic category | ||||||
| Initial treatment | 2250 | 94.61 | Referent | Referent | ||
| Re-treated | 245 | 10.30 | 1.62 (1.42–1.85) | < 0.001 | 1.65 (1.44–1.90) | < 0.001 |