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. 2021 Apr 8;11:7706. doi: 10.1038/s41598-021-86994-6

Table 3.

Results of risk factors analysis of treatment failed in TB patients.

Variables n Rate of treatment failed (per 1000 TB) Univariable analysis Multivariable analysis
OR (95%CI) P-value OR (95%CI) P-value
Gender
Males 2055 86.41 Referent Referent
Females 668 28.09 0.63 (0.57–0.68) < 0.001 0.72 (0.66–0.78) < 0.001
Age
0~ 148 6.22 Referent Referent
20~ 643 27.04 1.68 (1.41–2.01)  < 0.001 1.34 (1.12–1.62) 0.003
40~ 1140 47.94 3.05 (2.57–3.63) < 0.001 2.17 (1.80–2.61) < 0.001
60~ 792 33.30 2.47 (2.07–2.95) <0.001 1.89 (1.56–2.28) < 0.001
Nationality
Han 1789 75.23 Referent Referent
Miao 326 13.71 1.00 (0.89–1.13) 0.998 0.94 (0.83–1.06) 0.279
Buyi 239 10.05 1.13 (0.98–1.29) 0.089 1.08 (0.94–1.24) 0.289
Yi 77 3.24 1.95 (1.68–2.23) 0.993 0.99 (0.79–1.25) 0.946
Dong 98 4.12 1.00 (0.79–1.26) 0.862 0.83 (0.68–1.02) 0.083
Tujia 122 5.13 0.98 (0.80–1.21) 0.384 0.97 (0.81–1.17) 0.758
Others 72 3.03 0.92 (0.77–1.11) 0.016 0.80 (0.63–1.01) 0.058
Occupation
Peasant workers 2340 98.40 Referent Referent
Homemakers and unemployed persons 137 5.76 1.00 (0.84–1.19) 0.977 1.11 (0.93–1.33) 0.237
Students 131 5.51 0.56 (0.47–0.66) < 0.001 0.92 (0.76–1.11) 0.380
Retired persons and cadres and staff 43 1.81 0.78 (0.57–1.05) 0.104 0.77 (0.57–1.05) 0.059
Others 72 3.03 0.61 (0.48–0.77) < 0.001 0.72 (0.57–0.91) 0.007
Local registered residence
Yes 2489 104.67 Referent Referent
No 234 9.84 0.84 (0.74–0.97) 0.013 0.97 (0.84–1.11) 0.652
Source of patients
Clinical consultation 1323 55.63 Referent Referent
Referral 836 35.15 0.92 (0.84–1.00) 0.051 0.87 (0.80–0.95) 0.002
Following up 384 16.15 0.80 (0.71–0.89) < 0.001 0.86 (0.76–0.97) 0.011
Recommended for symptoms 96 4.04 1.84 (1.49–2.27) < 0.001 1.49 (1.20–1.84) < 0.001
Physical examinations 33 1.39 0.50 (0.35–0.71) < 0.001 0.98 (0.69–1.39) 0.897
Others 51 2.14 1.48 (1.12–1.96) 0.006 1.29 (0.97–1.71) 0.086
Clinical classification
Type I 0 0.00 Referent
Type II 25 1.05 10,145,695.39 (0.00) 0.996
Type III 2673 112.40 19,244,084.80 (0.00) 0.996
Type IV 25 1.05 6,785,381.10 (0.00) 0.996
Type V 0 0.00 1.00 (0.00) 1.000
Diagnosis
Etiological positivity 1758 73.93 Referent Referent
Etiological negative 950 39.95 0.26 (0.24–0.28) < 0.001 0.31 (0.29–0.34) < 0.001
Pure tuberculous pleurisy 11 0.46 0.11 (0.06–0.20) < 0.001 0.17 (0.09–0.30) < 0.001
Others 4 0.17 0.22 (0.08–0.59) 0.003 0.34 (0.13–0.91) 0.032
Severe cases
Yes 782 32.88 Referent Referent
No 1941 81.62 0.40 (0.36–0.43) < 0.001 0.48 (0.44–0.52)  < 0.001
Therapeutic category
Initial treatment 2224 93.52 Referent Referent
Re-treated 499 20.98 3.40 (3.08–3.75) < 0.001 1.87 (1.69–2.07) < 0.001