Table 5.
Results of risk factors analysis of switch to MDR in TB patients.
| Variables | n | Rate of switch to MDR (per 1000 TB) | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
| OR (95%CI) | P-value | OR (95%CI) | P-value | |||
| Gender | ||||||
| Males | 419 | 17.62 | Referent | Referent | ||
| Females | 150 | 6.31 | 0.69 (0.57–0.83) | < 0.001 | 0.90 (0.75–1.09) | 0.294 |
| Age | ||||||
| 0~ | 29 | 1.22 | Referent | Referent | ||
| 20~ | 179 | 7.53 | 2.39 (1.61–3.53) | < 0.001 | 1.39 (0.92–2.11) | 0.116 |
| 40~ | 234 | 9.84 | 3.17 (2.16–4.67) | < 0.001 | 1.49 (0.98–2.25) | 0.06 |
| 60~ | 127 | 5.34 | 2.01 (1.34–3.01) | 0.001 | 1.02 (0.66–1.57) | 0.938 |
| Nationality | ||||||
| Han | 424 | 17.83 | Referent | Referent | ||
| Miao | 53 | 2.23 | 0.69 (0.52–0.91) | 0.01 | 0.650.49–0.87) | 0.004 |
| Buyi | 16 | 0.67 | 0.32 (0.19–0.52) | < 0.001 | 0.32 (0.19–0.53) | < 0.001 |
| Yi | 19 | 0.80 | 1.04 (0.66–1.65) | 0.867 | 0.94 (0.59–1.50) | 0.801 |
| Dong | 15 | 0.63 | 0.63 (0.38–1.06) | 0.083 | 0.65 (0.39–1.09) | 0.104 |
| Tujia | 18 | 0.76 | 0.57 (0.36–0.92) | 0.021 | 0.78 (0.48–1.26) | 0.307 |
| Others | 24 | 1.01 | 1.06 (0.70–1.59) | 0.800 | 1.16 (0.77–1.76) | 0.481 |
| Occupation | ||||||
| Peasant workers | 436 | 18.33 | Referent | Referent | ||
| Homemakers and unemployed persons | 57 | 2.40 | 2.25 (1.70–2.96) | < 0.001 | 1.85 (1.38–2.47) | < 0.001 |
| Students | 32 | 1.35 | 0.73 (0.51–1.05) | 0.088 | 1.12 (0.76–1.64) | 0.570 |
| Retired persons and cadres and staff | 15 | 0.63 | 1.46 (0.87–2.45) | 0.149 | 1.71 (1.01–2.90) | 0.044 |
| Others | 29 | 1.22 | 1.33 (0.91–1.93) | 1.326 | 1.40 (0.95–2.06) | 0.087 |
| Local registered residence | ||||||
| Yes | 471 | 19.81 | Referent | Referent | ||
| No | 98 | 4.12 | 1.87 (1.51–2.33) | < 0.001 | 2.38 (1.88–3.01) | < 0.001 |
| Source of patients | ||||||
| Clinical consultation | 254 | 10.68 | Referent | Referent | ||
| Referral | 223 | 9.38 | 1.28 (1.07–1.53) | 0.008 | 1.43 (1.19–1.72) | < 0.001 |
| Following up | 56 | 2.35 | 0.61 (0.45–0.81) | 0.001 | 0.62 (0.46–0.83) | 0.002 |
| Recommended for symptoms | 12 | 0.50 | 1.19 (0.66–2.12) | 0.563 | 0.73 (0.40–1.32) | 0.292 |
| Physical examinations | 5 | 0.21 | 0.40 (0.16–0.96) | 0.041 | 1.00 (0.41–2.46) | 0.998 |
| Others | 19 | 0.80 | 2.87 (1.80–4.58) | < 0.001 | 1.62 (1.00–2.62) | 0.049 |
| Clinical classification | ||||||
| Type I | 0 | 0.00 | Referent | |||
| Type II | 3 | 0.13 | 1,210,203.72.39 (0.00) | 0.996 | ||
| Type III | 566 | 23.80 | 4,035,016.57 (0.00) | 0.996 | ||
| Type IV | 0 | 0.00 | 1.00 (0.00) | 1.000 | ||
| Type V | 0 | 0.00 | 1.00 (0.00) | 1.000 | ||
| Diagnosis | ||||||
| Etiological positivity | 520 | 21.87 | Referent | Referent | ||
| Etiological negative | 49 | 2.06 | 0.05 (0.03–0.06) | < 0.001 | 0.08 (0.06–0.11) | < 0.001 |
| Pure tuberculous pleurisy | 0 | 0.00 | 0.00 (0.00) | 0.979 | 0.00 (0.00) | 0.980 |
| Others | 0 | 0.00 | 0.00 (0.00) | 0.991 | 0.00 (0.00) | 0.991 |
| Severe cases | ||||||
| Yes | 199 | 8.37 | Referent | Referent | ||
| No | 370 | 15.56 | 0.30 (0.25–0.36) | < 0.001 | 0.42 (0.35–0.50) | < 0.001 |
| Therapeutic category | ||||||
| Initial treatment | 301 | 12.66 | Referent | Referent | ||
| re-treated | 268 | 11.27 | 16.95 (14.36–19.99) | < 0.001 | 8.14 (6.84–9.69) | < 0.001 |