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. 2021 Apr 8;11:7730. doi: 10.1038/s41598-021-87259-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Melanosomal amyloid formation by PMEL alanine-scanning mutants. (A) EM analysis of Epon-embedded stable Mel220 transfectants expressing PMEL alanine-scanning mutants. Melanosomes of mutants that form fibrils are shown. The respective quantification of fibril formation in the indicated cell lines is depicted in Suppl. Fig. S4 B–E and summarized in (B). (B) Quantitative EM analysis of PMEL alanine-scanning mutants. Shown is the number of fibril-containing organelles per cell [N = 15] after normalization to wt-PMEL (set to 1)). Essential (category 3), relevant (category 2), and largely dispensable residues (category 1) are colored in red, orange, and green, respectively.