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. 2021 Apr 8;11:7702. doi: 10.1038/s41598-021-87295-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fluorescence traces from individual wells (n = 4 per sample) of RT-QuIC reactions seeded with homogenates of ear punches collected from different regions of pinna apex (above the dashed line in Fig. 2). The RT-QuIC reactions (without IOME extraction, − IOME) were seeded with 10^–2 dilution of ear homogenate in 0.1% SDS/PBS/N2. For the IOME-RT-QuIC reactions, a 1:10 dilution of iron oxide magnetic beads in 0.1% SDS/PBS/N2 was prepared, and the reactions were seeded with ear tissue equivalents comparable to the 10^–2 dilution used in the reactions without IOME. ‘Weak positive’ and ‘strong positive’ labels refer to the ELISA positivity of RLN tissue from the same deer.