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. 2021 Apr 8;11:7700. doi: 10.1038/s41598-021-87307-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological signature of basmisanil in healthy volunteers. (a) Relative power change of EEG signals averaged across electrodes in response to basmisanil, separately for eyes open and eyes closed conditions at 1 and 4 h post morning dose after 14 days of 240 mg basmisanil treatment twice daily. (b) Relative power change of EEG signals averaged across electrodes in response to basmisanil (average of eyes open and eyes closed conditions, 1 h and 4 h post morning dose after 14 days of 240 mg basmisanil treatment twice daily) and in response to midazolam (grey: eyes open and eyes closed, 1 h post single dose of 2 mg). Black bars indicate significant effects for basmisanil (cluster randomization test). (c) Absolute power change of EEG signals averaged across all electrodes in response to basmisanil (average of eyes open and eyes closed conditions, 1 and 4 h post morning dose after 14 days of 240 mg basmisanil treatment twice daily). Black bar indicates significant effect (cluster randomization test). (d) Spatial distribution of power changes and p-values (derived from t-tests) for the two significant clusters identified for basmisanil (black bars in (b)). Top panel: power changes; bottom panel: p-values; left: low-frequency cluster (6.2–8.7 Hz); right: high-frequency cluster (13.5–38.0 Hz). CI confidence interval (uncorrected for multiple testing across frequencies). See Supplementary Fig. S5 for additional EEG analyses and Fig. 5 for basmisanil exposure and receptor occupancy ranges during EEG assessments.