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. 2021 Apr 8;11:7731. doi: 10.1038/s41598-021-86574-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genes involved in the production of Lipid A and attachment of O-antigen. (a) Intermediate metabolites are represented in bold and the presence or absence of a gene is represented in the table, with a crossed box indicating not present in all members. (b) Progressive elimination of lpxA, lpxB, and lpxD in the SoE. (c) Loss of lpxK kdsB, and adjacent genes. A double grey line indicates a region of approximately 15 kb containing several genes not shown here. Genes labeled ‘hypoth.’ or unlabeled indicate hypothetical proteins or interrupted CDS. Asterisk indicates a fragmented CDS. Numbers in parentheses correspond to genome sizes in Mb.