Table 1.
Demographics and characteristics of all eligible patients.
| Derivation set (n = 72) | Validation set (n = 253) | |||||
|---|---|---|---|---|---|---|
| RCVS (n = 41) | Non-RCVS (n = 31) | p | RCVS (n = 165) | Non-RCVS (n = 88) | p | |
| Age | 51 (45–59) | 43 (35–56) | 0.069 | 51 (44–56) | 53 (44–59) | 0.183 |
| Sex (female) | 36 (87.8) | 22 (71) | 0.014 | 128 (77.6) | 49 (55.7) | < 0.001 |
| Recurrent TCHs | 33 (80.5) | 9 (29) | < 0.001 | 148 (89.7) | 50 (56.8) | < 0.001 |
| Diagnosis of RCVS | ||||||
| Definite RCVS | 29 (70.7) | 128 (77.6) | ||||
| Probable RCVS | 12 (29.3) | 37 (28.9) | ||||
| Etiology of RCVS | ||||||
| Idiopathic | 35 (85.4) | 162 (98.2) | ||||
| Postpartum | 3 (7.3) | 0 (0.0) | ||||
| Vasoactive drugs | 3 (7.3) | 3 (1.8) | ||||
| Triggering factors for TCH | ||||||
| Single | 13 (31.7) | 4 (12.9) | 0.131 | 68 (41.2) | 30 (34.1) | 0.268 |
| Multiple | 21 (51.2) | 4 (12.9) | 0.001 | 61 (37.0) | 10 (11.4) | < 0.001 |
| Premorbid migraine | 4 (9.8) | 5 (16.1) | 0.485 | 29 (17.6) | 12 (13.6) | 0.418 |
| Focal neurological deficit | 3 (7.3) | 4 (12.9) | 0.454 | 17 (10.3) | 7 (8.0) | 0.544 |
| Seizure | 2 (4.9) | 0 (0.0) | 0.503 | 1 (0.6) | 0 (0.0) | > 0.999 |
| Ischemic stroke | 3 (7.3) | 0 (0.0) | 0.202 | 3/158 (1.8) | 1/78 (1.1) | > 0.999 |
| Parenchymal haemorrhage | 0 (0.0) | 0 (0.0) | 1 (0.6) | 0 (0.0) | > 0.999 | |
| PRES | 4 (9.8) | 0 (0.0) | 0.129 | 1 (0.6) | 0 (0.0) | > 0.999 |
| SAH | 2 (4.9) | 0 (0.0) | 0.503 | 8 (4.8) | 3 (3.4) | 0.756 |
| Convexity SAH | 2 (4.9) | 0 (0.0) | 8 (4.8) | 2 (2.3) | ||
| Non-convexity SAH | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (1.1) | ||
| Carotid artery involvement | 2 (4.9) | 0 (0.0) | 0.503 | 10 (6.1) | 7 (8.0) | 0.478 |
| BP surge | 19 (46.3) | 1 (3.2) | < 0.001 | 72/154 (46.8) | 7/77 (9.1) | < 0.001 |
Data are presented as median (IQR) or number (percent).
BP blood pressure, ICH intracerebral hemorrhage, PRES posterior reversible encephalopathy syndrome, SAH subarachnoid hemorrhage, TCH thunderclap headache.