Table 2.
Participant demographics
| All sites | Site 1 | Site 2 | Site 3 | Site 4 | Site 5 | Site 6 | Site 7 | Site 8 | |
|---|---|---|---|---|---|---|---|---|---|
| N = 2432 | N = 300 | N = 304 | N = 305 | N = 300 | N = 306 | n = 302 | N = 309 | N = 306 | |
| N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | N (%)/mean (SD) | |
| Age | |||||||||
| Age in years, mean (SD) | 28.1 (7.9) | 29 (8.1) | 29.8 (7.1) | 27.7 (7.8) | 30.8 (6.6) | 28.3 (7.3) | 22.9 (7.4) | 28.6 (8.6) | 27.4 (7.6) |
| Age categories n (%) | |||||||||
| 15–24 | 894 (36.8) | 94 (31.3) | 75 (24.7) | 117 (38.4) | 55 (18.3) | 106 (34.6) | 211 (69.9) | 114 (36.9) | 122 (39.9 |
| 25–34 | 976 (40.1) | 121 (40.3) | 144 (47.4) | 128 (42.0) | 152 (50.7) | 138 (45.1) | 63 (20.9) | 105 (34.0) | 125 (40.8) |
| 35–45 | 562 (23.1) | 85 (28.3) | 85 (28.0) | 60 (19.7) | 93 (31.0) | 62 (20.3) | 28 (9.3) | 90 (29.1) | 59 (19.3) |
| Sex n (%) | |||||||||
| Female | 1369 (56.9) | 170 (56.7) | 176 (57.9) | 173 (58.2) | 160 (53.9) | 193 (63.3) | 141 (48.8) | 177 (57.7) | 179 (58.5) |
| Male | 1036 (43.1) | 130 (43.3) | 128 (42.1) | 124 (41.8) | 137 (46.1) | 112 (36.7) | 148 (51.2) | 130 (42.3) | 127 (41.5) |
| Race n (%) | |||||||||
| Black or African American | 2237 (95.3) | 288 (97.0) | 290 (96.3) | 282 (96.2) | 249 (94.7) | 294 (96.7) | 276 (96.5) | 270 (90.0) | 288 (95.0) |
| Multi-racial | 80 (3.4) | 7 (2.4) | 8 (2.7) | 8 (2.7) | 5 (1.9) | 10 (3.3) | 6 (2.1) | 24 (8.0) | 12 (4.0) |
| Other | 30 (1.3) | 2 (0.7) | 3 (1.0) | 3 (1.0) | 9 (3.4) | 0 | 4 (1.4) | 6 (2.0) | 3 (1.0) |
| Sickle cell genotype n (%) | |||||||||
| Hb SS | 1675 (69.3) | 220 (73.3) | 216 (71.8) | 203 (67.9) | 200 (67.8) | 225 (73.5) | 195 (64.6) | 226 (73.1) | 190 (62.1) |
| Hb SC | 498 (20.6) | 54 (18.0) | 54 (17.9) | 66 (22.1) | 63 (21.4) | 56 (18.3) | 70 (23.2) | 56 (18.1) | 79 (25.8) |
| Hb S beta + thalassemia | 131 (5.4) | 15 (5.0) | 18 (6.0) | 15 (5.0) | 14 (4.7) | 18 (5.9) | 17 (5.6) | 18 (5.8) | 16 (5.2) |
| Hb S beta0 thalassemia | 89 (3.7) | 10 (3.3) | 11 (3.7) | 12 (4.0) | 16 (5.4) | 4 (1.3) | 17 (5.6) | 6 (1.9) | 13 (4.2) |
| Hb S hereditary persistence of fetal Hb(S/HPFH) | 14 (0.6) | 0 | 1 (0.3) | 1 (0.3) | 2 (0.7) | 1 (0.3) | 2 (0.7) | 0 | 7 (2.3) |
| Hb SO | 4 (0.2) | 1 (0.3) | 0 | 1 (0.3) | 0 | 0 | 0 | 2 (0.6) | 0 |
| Hb SD | 6 (0.2) | 0 | 1 (0.3) | 1 (0.3) | 0 | 2 (0.7) | 1 (0.3) | 0 | 1 (0.3) |
| Hb SE | 1 (0.0) | 0 | 0 | 0 | 0 | 0 | 0 | 1 (0.3) | 0 |