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. 2021 Apr 8;12:2111. doi: 10.1038/s41467-021-22217-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Electron microscopy analysis of replication intermediates and four-way junctions-intermediates in WT and sgs1, top3, smc5/6 mutants. The plot indicates the percentage of various types of DNA replication intermediates (forks and bubbles) and Joint Molecules (JMs) divided in reversed forks, double Holliday Junctions (dHJs) and hemicatenanes. The number (n) of DNA molecules analysed for each genotype is indicated. The intermediates are derived from two biological replicates, with similar results. Typical examples of the visualized categories of JMs are shown with the entire DNA structure and enlarged views of the junction point, with schematic representation of ssDNA regions in red and dsDNA regions in black. The length of the four branches composing the JMs and their relationship in terms of length is shown. Scale bars of 180 nm corresponding to 500 base pairs are indicated. Source data are provided as a Source Data file.