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. 2021 Mar 26;8:653787. doi: 10.3389/fmolb.2021.653787

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Copyright © 2021 Jia, Wang, Qiao, Ren, Xing, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The impact of PANDAR knockdown on proliferation and apoptosis of OSCC cells. (A) The relative expression level of PANDAR in cancerous cell lines and normal cell line. (B) The knockdown efficiency of specific sgRNAs targeting PANDAR was detected in OSCC cells by qRT-PCR. (C–E) Cell proliferation assays (CCK-8 and EdU) and cell apoptosis assay (caspase-3 activity assay) were carried out to assess the functional role of PANDAR knockdown in OSCC. Data were represented as the mean values (±SD) of three independent experiments. ^* p < 0.05, significantly different from the control.