FIGURE 5.

Role of the endothelium and NO for Na₂S and GYY4137 relaxation (A) Average relaxations induced by acetylcholine (ACh) in the absence (n = 7) and the presence of either L-NAME (100 µM) (n = 6) or L-cysteine (1 mM) (n = 7) in rat mesenteric arteries (B) Na₂S induced vascular relaxation in vessels with (n = 11) and without endothelium (n = 5), or with endothelium in the presence of an NO synthase inhibitor, L-NAME (n = 6) (C) GYY4137 induced vascular relaxation in vessels with (n = 12) and without endothelium (n = 6) or with endothelium in the presence L-NAME (n = 6). Where no error bars are indicated, error lies within dimensions of symbol. All data are means ± SEM. *p < 0.05, two-way ANOVA.