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. 2021 Mar 26;15:649982. doi: 10.3389/fnins.2021.649982

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Copyright © 2021 Shi, Tian, Cai, Yang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DAPK1 was identified as a target gene of miR-124. DAPK1 levels were measured by western blotting (A) and quantitatively analyzed (B,C). Data are presented as mean ± SD (n = 4/group). **p < 0.01, ***p < 0.001 vs. Con or Sham group. N2a cells were transfected with miR-124 (oe-miR-124) or control-treated (oe-control) cells. Levels of miR-124 and DAPK1 mRNA were measured by qRT-PCR (D). Levels of DAPK1, caspase-3, cleaved caspase-3, p35/25, ERK1/2, and p-ERK1/2 were measured by western blotting (E) and quantitatively analyzed (F). Data are presented as mean ± SD (n = 4/group). **p < 0.01, ***p < 0.001 vs. oe-control group.