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. 2021 Mar 26;15:649982. doi: 10.3389/fnins.2021.649982

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Copyright © 2021 Shi, Tian, Cai, Yang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of miR-124 on neuroexcitatory toxicity. (A) The relative cell viabilities of primary cultured neurons were evaluated using a cell counting kit-8 (CCK8) assay after NMDA treatment (20 μM for 15 min) (n = 6/group). (B) TUNEL staining was performed in primary cultured neurons after NMDA treatment with different miR-124 levels (scale bar = 50 μm) and quantified (C). Levels of DAPK1, caspase-3, cleaved caspase-3, CaMK2, and p-CaMK2 were measured by western blotting (D) and quantitatively analyzed (E). Data are presented as mean ± SD (n = 4/group). *p < 0.05, **p < 0.01, ***p < 0.001 vs. Con, ^#p < 0.05, ^##p < 0.01 vs. NMDA group.