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. 2021 Mar 26;15:649982. doi: 10.3389/fnins.2021.649982

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Copyright © 2021 Shi, Tian, Cai, Yang and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-124 protected against PIT-stroke damage. (A) TUNEL staining was performed in primary cultured neurons after OGD treatment with different miR-124 levels (scale bar = 50 μm) and quantified (B). Data are presented as mean ± SD (n = 4/group). **p < 0.01 vs. Con, ^##p < 0.01 vs. OGD group. (C) Representative images of TTC staining depicting Ago-miR-124-induced protection against PIT-stroke damage. Levels of DAPK1, caspase-3, and cleaved caspase-3 were measured by western blotting (D) and quantitatively analyzed (E). Neurological scores (F) and performance on the rotarod test (G) were tested on day 1, day 3, and day 7 after PIT-stroke among different groups. Data are presented as mean ± SD (n = 6/group). **p < 0.01, ***p < 0.001 vs. Con, ^#p < 0.05, ^##p < 0.01 vs. OGD group.