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. 2021 Mar 24;53(1):166–219. doi: 10.3947/ic.2021.0303

Table 1. Classification of severity of illness referred by National Institutes of Health.

Severity of illness Definition
1. Asymptomatic Individuals who test positive for SARS-CoV-2 using a virologic test (i.e., a nucleic acid amplification test or an antigen test), but who have no symptoms that are consistent with COVID-19.
2. Mild Individuals who have any of the various signs and symptoms of COVID-19 (e.g., fever, cough, sore throat, malaise, headache, muscle pain, nausea, vomiting, diarrhea, loss of taste and smell) but who do not have shortness of breath, dyspnea, or abnormal chest imaging.
3. Moderate Individuals who show evidence of lower respiratory disease during clinical assessment or imaging and who have saturation of oxygen (SpO2) ≥94% on room air at sea level.
4. Severe Individuals who have SpO2 <94% on room air at sea level, a ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2) <300 mmHg, respiratory frequency >30 breaths per minute, or lung infiltrates >50%.
5. Critical Individuals who have respiratory failure, septic shock, and/or multiple organ dysfunction.

Source: NIH. Clinical Spectrum of SARS-CoV-2 Infection. Available at: https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/ [2].

SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019; SpO2, saturation of percutaneous oxygen; PaO2, partial pressure of oxygen; FiO2, fraction of Inspired oxygen.