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. 2021 Mar 26;8:642296. doi: 10.3389/fmed.2021.642296

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Copyright © 2021 Portolés, Martín, Broseta and Cases.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of HIF under normoxic conditions, pharmacological effects of hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) and under hypoxic conditions. HIF, hypoxia-inducible factor; O₂, oxygen; OH, hydroxyl; PHD, prolyl hydroxylase domain protein; HIF-PHI, hypoxia inducible factor prolyl hydroxylase inhibitor; pVHL, Von Hippel Lindau protein; FIH-1, Factor inhibiting HIF; CBP, CREB-binding protein.