Table 1.

Immunological evaluation of a patient with Down syndrome disintegrative disorder.

	Result and reference range
Immunologic measures
Autoimmune encephalopathy panel (serum)	See Supplementary Table 1
Anti-cardiolipin antibody	Anti-cardiolipin IgG = 1 (≤ 15 units); IgM = 5 (≤ 14 units); IgA = 1 (≤ 14 units)
Angiotensin-converting enzyme	50 (22-108 U/L)
Anti-Beta-2-glycoprotein 1	IgG = 1 (≤ 20 units); IgM = 2 (≤ 20 units); IgA = 1 (≤ 20 units)
Von willebrand factor	89.0 (40.0–190.0%)
Lupus anticoagulant panel	See Supplementary Table 2
Anti-thyroglobulin antibodies	<1.8 (<4.0 IU/mL)
Anti-microsomal (thyroperoxidase) antibodies	0.9 (<9.0 IU/mL)
Anti-nuclear antibody screen	Positive (1:40 Speckled)
Anti-streptolysin O	469 (≤ 99 IU/mL)
Basic laboratory measures
Complete blood count	See Supplementary Table 3
Sedimentation rate	2 (0–13 mm/h)
C-reactive protein	<0.02 (≤ 0.60 mg/dL)
Comprehensive metabolic panel	See Supplementary Table 4
Thyroid stimulating hormone	2.229 (0.200–4.500 IUI/mL)
Cerebrospinal fluid analyses
Cell counts	See Supplementary Table 5
Glucose	61 (60–80 mg/dL)
Protein	34 (15–45 mg/dL)