TABLE 2.

Astrocyte and pericyte biological processes.

Molecular signaling	Function		NDD Pathology
	Pericyte	BBB/NVU	RAC	Other
PDGF/PDGFR	Activation, differentiation, recruitment	Endothelial transcytosis barrier, integrity	Angiogenesis, inflammation
Laminins/dystrophin, dystroglycan	Homeostasis	Astrocytic end feet polarization, integrity		Aβ accumulation
ApoE/LRP1	Loss	Breakdown		Aβ aggregation, microhemorrhages, microinfarct
CXCL12/CXCR4		Neurotrophic release		Microglia activation, WML

Some molecular crosstalk between astrocyte and pericyte has been summarized. Other Wnt crosstalk, JAK-STAT, Notch, Shh may also be involved through the interaction with above molecules.