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. 2021 Mar 26;15:629323. doi: 10.3389/fnins.2021.629323

TABLE 7.

Studies and experimental characteristics of tES literature for PD.

Authors Subjects Stimulation parameters
Neuroimaging
Conclusion
Type Current Duration Location Type Feature
Del Felice et al., 2019 15 tACS++tRNS 4 or 30 Hz, 1 to 2 mA, 30 min 5 sessions per week for two weeks Anode: The location of power spectral difference was detected, cathode: ipsilateral mastoid EEG Power spectral in delta (1–4 Hz), theta band (4.5–7.5 Hz), alpha1 (8–10 Hz), alpha2 (10.5–12.5 Hz), beta (13—0 Hz) Individualized tACS in PD improves motor and cognitive performance. These changes are associated with a reduction of excessive fast EEG oscillations.
Beretta et al., 2020 24 tDCS 1 and 2 mA, 20 min 3 sessions 2 weeks apart Anode: primary motor cortex, cathode: contralateral supraorbital region fNIRS The concentration changes of HbO tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA, and was inefficient in modifying the habituation of perturbation
Schoellmann et al., 2019 21 tDCS 1 mA, 20 min 1 session Anode: left sensorimotor (C3), cathode: right frontal area (FP2). EEG Frequency domain spectrum and coherence tDCS improved PD motor symptoms. Neurophysiological features indicated amotor-task-specific modulation of activityand coherence from 22 to 27 Hz after ‘verum’stimulation in PD.
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