TABLE 7.
Studies and experimental characteristics of tES literature for PD.
Authors | Subjects |
Stimulation parameters |
Neuroimaging |
Conclusion | ||||
Type | Current | Duration | Location | Type | Feature | |||
Del Felice et al., 2019 | 15 | tACS++tRNS | 4 or 30 Hz, 1 to 2 mA, 30 min | 5 sessions per week for two weeks | Anode: The location of power spectral difference was detected, cathode: ipsilateral mastoid | EEG | Power spectral in delta (1–4 Hz), theta band (4.5–7.5 Hz), alpha1 (8–10 Hz), alpha2 (10.5–12.5 Hz), beta (13—0 Hz) | Individualized tACS in PD improves motor and cognitive performance. These changes are associated with a reduction of excessive fast EEG oscillations. |
Beretta et al., 2020 | 24 | tDCS | 1 and 2 mA, 20 min | 3 sessions 2 weeks apart | Anode: primary motor cortex, cathode: contralateral supraorbital region | fNIRS | The concentration changes of HbO | tDCS over M1 improved the postural response to external perturbation in PD, with better response observed for 2 mA compared with 1 mA, and was inefficient in modifying the habituation of perturbation |
Schoellmann et al., 2019 | 21 | tDCS | 1 mA, 20 min | 1 session | Anode: left sensorimotor (C3), cathode: right frontal area (FP2). | EEG | Frequency domain spectrum and coherence | tDCS improved PD motor symptoms. Neurophysiological features indicated amotor-task-specific modulation of activityand coherence from 22 to 27 Hz after ‘verum’stimulation in PD. |