Table 2.

Summary of main genetic associations with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis through genome-wide association studies, according to ANCA subgroups.

Subgroups	Chr	Reported Gene(s)	SNP	Population	Cases-Controls	P-value	OR	Reference
PR3+ AAV	6p21.32	HLA−DP	rs3117242	European	1521-6858	6.2×10−89	7.03	22808956
	6p21.32	HLA–DPB1	rs141530233	European	1361-4723	1.33×10-106	6.19	28029757
	6p21.32	HLA–DPB1	rs1042169	European	1361-4723	6.53×10−106	6.09	28029757
	6p21.32	HLA–DPA1	rs9277341	European	1361-4723	4.52×10-84	3.69	28029757
	6p21.32	HLA–DQA1	rs35242582	European	1361-4723	5.78×10−18	1.62	28029757
	6p21.32	SERPINA1	rs28929474	European	1361-4723	1.29×10−13	2.43	28029757
	19p13.3	PRTN3	rs62132295(A)	European	1521-1599	2.6×10−7	0.73	22808956
	19p13.3	PRTN3	rs62132293	European	1361-4723	3.59×10−13	1.39	28029757
	6q22.33	ARHGAP18	rs1705767	European	1521-6858	5.2×10−8	0.73	22808956
	14q32.13	SERPINA1	rs7151526	European	1521-6858	5.6×10−12	0.53	22808956
	Xp22.2	MOSPD2	rs6628825	European	1521-6858	6.1×10−7	0.77	22808956
MPO+ AAV	6p21.32	HLA-DQ	rs5000634	European	556-6858	2.1×10−8	0.65	22808956
	6p21.32	HLA–DQA2	rs3998159	European	378-4723	5.24×10-25	2.72	28029757
	6p21.32	HLA–DQA2	rs7454108	European	378-4723	5.03×10-25	2.73	28029757
MPO- AAV	6p21.32	HLA–DQB1	rs1049072	European	378-4723	2.13×10-24	2.37	28029757