Table 3.
Summary of genetic associations with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis excluding those derived from genome-wide association studies.
| Gene | Variation | Disease | Populations | 
|---|---|---|---|
| HLA | DQA1*0302, DQB1*0303, DPB1*04:01, DRB1*0901, DRB1*1101, DRB1*13:02, HLA–DPA1, HLA–DQA2 | AAV (GPA, MPA, EGPA) | Worldwide | 
| RING | rs213210, rs213209, and rs213208 | GPA | German | 
| RXRB | rs6531 | GPA | German | 
| CD226 | rs763361 | GPA | German | 
| CTLA4 | rs3087243, CT60 | GPA, MPA and EGPA | British, Swedish | 
| DEFB4 | High CNVs | AAV | Chinese | 
| DSP | rs2076295G | MPA | Japanese | 
| ETS1 | rs1128334 | GPA | Japanese | 
| FCGR3B | Low CNVs, High CNVs | AAV | French, British, Chinese | 
| IL10 | IL10 -3575/-1082/-592 TAC haplotype | EGPA( ANCA- ) | German | 
| IL2RA | rs41295061 | AAV | British | 
| MUC5B | rs35705950 | AAV-ILD | Japanese | 
| PTPN22 | rs2476601, C1858T | GPA, MPA | German, Italian, British | 
| TLR-9 | rs352162, rs352140, rs352139 CTC, TCT | GPA, MPA, EGPA | German, British, Dutch | 
| TERT | rs2736100A | MPA | Japanese |