Table 1.
Associations of PIK3CA exon 9 and 20 mutation status with clinicopathologic characteristics.
| Characteristics | No. of patients(n = 5733) | Mutant PIK3CA exon 9 (n = 511) | Wild-type PIK3CA exon 9 (n = 5222) | p | Mutant PIK3CA exon 20 (n = 270) | Wild-type PIK3CA exon 20 (n = 5463) | p |
|---|---|---|---|---|---|---|---|
| Gender | 0.123 | 0.335 | |||||
| Male | 3492 (60.9%) | 295 (8.4%) | 3197 (91.6%) | 172 (4.9%) | 3320 (95.1%) | ||
| Female | 2241 (39.1%) | 216 (9.6%) | 2025 (90.4%) | 98 (4.4%) | 2143 (95.6%) | ||
| Age, years | 0.4531 | 0.0011 | |||||
| Mean(SD) | 58.8 (12.9) | 59.1 (13.7) | 58.7 (12.9) | 55.9 (13.8) | 58.9 (12.9) | ||
| Median | 60.0 | 60.0 | 60.0 | 58.0 | 60.0 | ||
| Range | 17.0-96.0 | 23.0-95.0 | 17.0-96.0 | 18.0-89.0 | 17.0-96.0 | ||
| Age, years | 0.084 | <0.001 | |||||
| <45 | 794 (13.8%) | 79 (9.9%) | 715 (90.1%) | 57 (7.2%) | 737 (92.8%) | ||
| 45-49 | 539 (9.4%) | 39 (7.2%) | 500 (92.8%) | 33 (6.1%) | 506 (93.9%) | ||
| 50-75 | 3852 (67.2%) | 332 (8.6%) | 3520 (91.4%) | 159 (4.1%) | 3693 (95.9%) | ||
| >75 | 548 (9.6%) | 61 (11.1%) | 487 (88.9%) | 21 (3.8%) | 527 (96.2%) | ||
| Tumor site | <0.001 | <0.001 | |||||
| Rectum | 2717 (47.4%) | 184 (6.8%) | 2533 (93.2%) | 96 (3.5%) | 2621 (96.5%) | ||
| Left colon* | 1773 (30.9%) | 161 (9.1%) | 1612 (90.9%) | 62 (3.5%) | 1711 (96.5%) | ||
| Right colon* | 1241 (21.6%) | 166 (13.4%) | 1075 (86.6%) | 112 (9.0%) | 1129 (91.0%) | ||
| Differentiation of tubular adenocarcinoma | 0.012 | 0.902 | |||||
| Well | 932 (17.6%) | 89 (9.5%) | 843 (90.5%) | 40 (4.3%) | 892 (95.7%) | ||
| Moderate | 3954 (74.6%) | 352 (8.9%) | 3602 (91.1%) | 180 (4.6%) | 3774 (95.4%) | ||
| Poor | 415 (7.8%) | 20 (4.8%) | 395 (95.2%) | 20 (4.8%) | 395 (95.2%) | ||
| Nontubular adenocarcinoma |
432 | 50 | 382 | 30 | 402 | ||
| PIK3CA exon 9 status | – | 0.002 | |||||
| Wild type | 5222 (91.1%) | 260 (5.0%) | 4962 (95.0%) | ||||
| Mutant | 511 (8.9%) | 10 (2.0%) | 501 (98.0%) | ||||
| PIK3CA exon 20 status | 0.002 | – | |||||
| Wild type | 5463 (95.3%) | 501 (9.2%) | 4962 (90.8%) | ||||
| Mutant | 270 (4.7%) | 10 (3.7%) | 260 (96.3%) | ||||
| KRAS exon 2 status | <0.001 | <0.001 | |||||
| Wild type | 3459 (60.3%) | 184 (5.3%) | 3275 (94.7%) | 131 (3.8%) | 3328 (96.2%) | ||
| Mutant | 2274 (39.7%) | 327 (14.4%) | 1947 (85.6%) | 139(6.1%) | 2135 (93.9%) | ||
| BRAFV600E status | 1.000 | 0.365 | |||||
| Wild type | 5555 (96.9%) | 495 (8.9%) | 5060 (91.1%) | 259 (4.7%) | 5296 (95.3%) | ||
| Mutant | 178 (3.1%) | 16 (9.0%) | 162 (91.0%) | 11 (6.2%) | 167 (93.8%) |
*Left colon: descending colon, sigmoid colon, and rectosigmoid; Right colon: cecum, ascending colon and transverse colon.
Spearman Chi-square test.
1Mann-Whitney U test.