TABLE 2.

Reduction of tissue activity levels by local or combined local and systemic DTPA treatment following MOX contamination.

Contaminant	DTPA treatment	Wound			Lungs
		Leg	Skeleton	Liver	Lungs	Skeleton	Liver
MOX	Local	12 ± 15	67 ± 10	73 ± 3	6 ± 2	82 ± 6	73 ± 11
	Local + i.v.	14 ± 8	84 ± 6	81 ± 3	12 ± 3	97 ± 3	80 ± 24

Animals were contaminated by MOX inhalation or deposition in a wound and received DTPA treatment as described. Local administration (“Local”) to lungs (DTPA powder insufflation; about 5 µmol/kg) or wound (DTPA solution injection into the wound site; 30 µmol/kg) was started at 2 h. For combined local and systemic DTPA treatment (“Local + i.v.”) animals received the local dose at 2 h then two intravenous DTPA per week from day one to day 20 (30 µmol/kg). Animals were euthanized 21 days after contamination and skeletal and liver activity levels measured. Data are expressed as a percentage reduction as compared with untreated animals with four to six animals/group.