TABLE 3.

Comparative efficacy of two different DTPA treatment protocols on tissue Pu and Am levels.

	Bone				Liver
	% Initial activity	Inhibition (%)	% Initial activity	% Inhibition	% Initial activity	% Inhibition	% Initial activity	% Inhibition
Treatment	Pu		Am		Pu		Am
(A): Inhalation
None	0.182 ± 0.043		0.063 ± 0.016		0.041 ± 0.022		0.049 ± 0.018
Local	0.037 ± 0.017	80	0.008 ± 0.02	87	0.016 ± 0.007	61	0.011 ± 0.004	78
Local + i.v.	0.009 ± 0.006*	95	0.002 ± 0.001*	97	0.008 ± 0.004	81	0.004 ± 0.001*	92
Difference local vs local + i.v.	*p < 0.05		* p < 0.05		NS		*p < 0.05
(B): Wound
None	0.523 ± 0.080		0.264 ± 0.075		0.052 ± 0.009		0.067 ± 0.015
Local	0.188 ± 0.041	64	0.072 ± 0.007	73	0.024 ± 0.008	54	0.023 ± 0.009	66
Local + i.v.	0.089 ± 0.048**	83	0.039 ± 0.015***	85	0.013 ± 0.012	75	0.004 ± 0.002**	95
Difference local vs local + i.v.	**p < 0.01		*** p < 0.005		NS		** p < 0.01

Animals were contaminated by MOX inhalation or deposition in a wound and received DTPA treatment as described. Data are expressed as a percentage of the initial total activity and as % inhibition (reduction in tissue activity as compared with untreated animals with 4–6 animals/group). Data were compared between the two treatment groups using a two-tailed unpaired t test. p values are also given.