TABLE 4.
Comparative efficacy of two different DTPA treatment protocols on tissue levels and urinary excretion of activity.
| Contaminant | DTPA treatment | Wound | Inhalation | ||||
|---|---|---|---|---|---|---|---|
| Wound site | Systemic | Urine | Lungs | Systemic | Urine | ||
| Pu nitrate | i.v. | ↘ | ↘ | ↗ | ↘ | ↘ | ↗ 1 |
| Local | ↘ | ↘ | ↗ | ↘ | ↘ | ↗ 1 | |
| MOX | Local | 0 | ↘ | ↗ | 0 | ↘ | ↗ |
| Local + i.v. | 0 | ↘↘ | ↗ | 0 | ↘↘ | ↗ | |
“Systemic” represents skeleton plus liver the main retention organs for Pu/Am after transfer to the circulation. The arrows represent the change in percentage reduction either decrease or increase. For insoluble actinides (MOX), two arrows mean greater inhibition than one arrow (combined treatment “Local + i.v.” vs. local treatment “Local”)
1
Includes published data from Grémy et al., 2012.