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. 2021 Mar 26;11:654684. doi: 10.3389/fonc.2021.654684

Table 1.

The expression of CD276 in tumors and its relationship with pathological features.

Tumor type Expression Clinical significance Reference
Bladder cancer High Not reported (3)
Endometrial cancer High Associated with poor prognosis and TNM stages (4)
Pancreatic cancer High Associated with lymph node migration, tumor size, TNM stages, and cancer recurrence (5, 6)
Cervical cancer High Associated with poor prognosis and tumor size (7)
Breast cancer High Associated with poor prognosis, tumor size, TNM stages, lymph node migration, and cancer recurrence (8, 9)
Intrahepatic cholangiocarcinoma High Associated with poor prognosis, lymph node migration, tumor’s progression, and cancer recurrence (10)
Colorectal cancer High (membrane, cytoplasm, and nuclei) Associated with poor prognosis, TNM stages, lymph node migration, and cancer recurrence (11)
Ovarian cancer High (membrane, cytoplasm, and tumor endothelium) Associated with poor prognosis and TNM stages (12)
Glioma High Associated with TNM stages (13)
Melanoma High Associated with poor prognosis and TNM stages (14)
Lung cancer High Associated with poor prognosis, TNM stages, lymph node migration, and cancer
Recurrence
(15, 16)
Liver cancer High Associated with poor prognosis, lymph node migration, tumor’s progression, and TNM stages (17)
Prostatic cancer High Associated with poor prognosis, lymph node migration, tumor’s progression, TNM stages, and cancer recurrence (18, 19)
Oral squamous cell carcinoma High Associated with poor prognosis, tumor size, and TNM stages (20)
Kidney cancer High (tumor vessels and tumor cells) Associated with poor prognosis, tumor size, and TNM stages (21)
Pancreatic cancer High Positively correlated to the prognosis of patients (22)
Gastric cancer High Positively correlated to the prognosis of patients (24)
Adrenocortical carcinoma High (membrane, cytoplasm, and tumor vessels) Negatively correlated to the prognosis of patients Associated with tumor size and TNM stages (25)