Table 1.
The expression of CD276 in tumors and its relationship with pathological features.
| Tumor type | Expression | Clinical significance | Reference |
|---|---|---|---|
| Bladder cancer | High | Not reported | (3) |
| Endometrial cancer | High | Associated with poor prognosis and TNM stages | (4) |
| Pancreatic cancer | High | Associated with lymph node migration, tumor size, TNM stages, and cancer recurrence | (5, 6) |
| Cervical cancer | High | Associated with poor prognosis and tumor size | (7) |
| Breast cancer | High | Associated with poor prognosis, tumor size, TNM stages, lymph node migration, and cancer recurrence | (8, 9) |
| Intrahepatic cholangiocarcinoma | High | Associated with poor prognosis, lymph node migration, tumor’s progression, and cancer recurrence | (10) |
| Colorectal cancer | High (membrane, cytoplasm, and nuclei) | Associated with poor prognosis, TNM stages, lymph node migration, and cancer recurrence | (11) |
| Ovarian cancer | High (membrane, cytoplasm, and tumor endothelium) | Associated with poor prognosis and TNM stages | (12) |
| Glioma | High | Associated with TNM stages | (13) |
| Melanoma | High | Associated with poor prognosis and TNM stages | (14) |
| Lung cancer | High | Associated with poor prognosis, TNM stages, lymph node migration, and cancer Recurrence |
(15, 16) |
| Liver cancer | High | Associated with poor prognosis, lymph node migration, tumor’s progression, and TNM stages | (17) |
| Prostatic cancer | High | Associated with poor prognosis, lymph node migration, tumor’s progression, TNM stages, and cancer recurrence | (18, 19) |
| Oral squamous cell carcinoma | High | Associated with poor prognosis, tumor size, and TNM stages | (20) |
| Kidney cancer | High (tumor vessels and tumor cells) | Associated with poor prognosis, tumor size, and TNM stages | (21) |
| Pancreatic cancer | High | Positively correlated to the prognosis of patients | (22) |
| Gastric cancer | High | Positively correlated to the prognosis of patients | (24) |
| Adrenocortical carcinoma | High (membrane, cytoplasm, and tumor vessels) | Negatively correlated to the prognosis of patients Associated with tumor size and TNM stages | (25) |