ROBINS-I Assessment of Non-randomized studies: D1, Bias due to confounding; D2, Bias in selection of participants into the study; D3, Bias in classification of interventions; D4, Bias due to deviations from intended interventions; D5, Bias due to missing data; D6, Dias in measurement of outcomes; D7, Bias in selection of the reported result; X, high; –, some concern; +, low.