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. 2021 Mar 26;11:561247. doi: 10.3389/fonc.2021.561247

Figure 2.

Figure 2

The expression levels of AKT pS473, PCK1 pS90, INSIG1 pS207/INSIG2 pS151, and nuclear SREBP1 were upregulated in NSCLC specimens. IHC staining of 451 paired NSCLC specimens with their adjacent tissues was performed with the indicated specificity-validated antibodies. (A) Representative IHC staining of low and high levels of AKT pS473, PCK1 pS90, INSIG1 pS207/INSIG2 pS151, and nuclear SREBP1 expression in LUAD tissues and normal tissues. (B) Expression levels of AKT pS473, PCK1 pS90, INSIG1 pS207/INSIG2 pS151, and nuclear SREBP1 in LUAD tissues (n = 306) and normal tissues (n = 302). (C) Representative IHC staining of low and high expression levels of AKT pS473, PCK1 pS90, INSIG1 pS207/INSIG2 pS151, and nuclear SREBP1 in LUSC tissues and normal tissues. (D) Expression levels of AKT pS473, PCK1 pS90, INSIG1 pS207/INSIG2 pS151, and nuclear SREBP1 in LUSC tissues (n = 145) and normal tissues (n = 145).