Table 2.

Time-kill curves for fosfomycin (FOF) plus amikacin (AMK) and fosfomycin (FOF) plus gentamicin (GEN) against four clinical strains of carbapenemase producing strains.

Strains	Effect of the antibiotic combination (grow time[s][h])
	FOF + AK	FOF + GEN
VIM-1	Synergy (*) and bactericidal effect	Indifference
VIM-1/DHA-1	Synergy (*) and bactericidal effect	Indifference
OXA-48 plus CTX-M-15	Synergy (**) and bactericidal effect	Indifference
KPC-3 (TEM-1 and SHV-11)	Indifference	Synergy (*)

FOF, fosfomycin; AK, amikacin; GEN, gentamicin.

^*at 24 h;

^**at 6 and 24 h.