Table 3.
Pharmacokinetic profiles of fosfomycin, amikacin and gentamicin in mice serum.
| Antimicrobial [dose (mg/kg), route of administration] | Drug | Cmax (mg/L) | t1/2 (h) | AUC0−24 (mg·h/L) |
|---|---|---|---|---|
| FOF (500, ip.) | tFOF | 1354.09 | 1.07 | 2695.35 |
| fFOF | 1340.55 | 1.09 | 2668.35 | |
| AK (15, ip.) | tAK | 35.93 | 0.27 | 85.24 |
| fAK | 27.93 | 0.27 | 63.06 | |
| GEN (5, ip.) | tGEN | 21.03 | 0.43 | 40.23 |
| fGEN | 14.72 | 0.37 | 28.16 |
FOF, fosfomicin; AK, amikacin; GEN, gentamicin; tFOF, total fosfomicin; fFOF, free fosfomicin; tAK, total amikacin; fAK, free amikacin; tGEN, total gentamicin; fGEN, free gentamicim; ip., intraperitoneal; Cmax, maximum concentration of drug in serum; t1/2, half-life; AUC0−24, area under the concentration-time curve from 0-24 h; fAUC0−24, free AUC0−24.