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. 2021 Mar 26;11:625838. doi: 10.3389/fonc.2021.625838

Figure 2.

Figure 2

APOBEC3B expression is elevated in aggressive glioma and related to poor prognosis. (A) Chromosome localization and gene structure of APOBEC3B in human. (B) Structure of APOBEC3B. (C) Comparison of protein sequences encoded by APOBEC3B among seven different species. (D) Representative images of IHC staining for APOBEC3B in different pathological grades of gliomas [WHO II (27), WHO III (12), WHO IV (19)]. (E) Quantification of APOBEC3B IHC staining regarding the positive rate. (F) Quantification of APOBEC3B IHC staining regarding the H-score. (G) Overall survival based on high vs low expression of APOBEC3B in glioma patients (n = 27). The patients were stratified according to the H score of APOBEC3B in IHC staining. The H score has the range of 0–12. High group was defined as expression intensity >=6. Low group was defined as expression intensity <6. NS, Not Statistically Significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.