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. 2021 Mar 26;11:625838. doi: 10.3389/fonc.2021.625838

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Copyright © 2021 Zhang, Chen, Wang, Dai, Hu, Zhang, Hu, Liu and Cheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Landscape of somatic mutation in APOBEC3B^high and APOBEC3B^low groups. (A–C) the comparisons of mutation frequencies of (A) every mutation type classified by effects, (B) SNVs, (C) INDEL and SNP. (D) Forest plot shows the top 10 most significantly differentially mutated genes between two groups. Common carcinogenic pathways in (E) APOBEC3B^low and (G) APOBEC3N^high group. The heatmap indicates the mutually exclusive mutations and co-occurring of the frequently mutated genes in (F) APOBEC3B^low and (H) APOBEC3N^high groups. NS, Not Statistically Significant; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.