Table 5.
Impact of TLR2 Arg753Gln and TLR4 (Thr399Ile & Asp299Gly) Genotype Variants Regarding Sepsis among AML Patients
| Genotypes | AML |
Relative risk in AML |
|||||
|---|---|---|---|---|---|---|---|
| Absence of sepsis | Presence of Sepsis | OR | 95%CI | P value | |||
| (N=100) | (N=20) | ||||||
| TLR2 Arg753Gln | AA | 90 | 5 | 1 | - | - | R |
| AG | 6 | 9 | 21.37 | 3.28 | 139.1 | 0.001 | |
| GG | 4 | 6 | 30.33 | 1.31 | 697.6 | 0.032 | |
| A | 186 | 19 | 17.64 | 3.632 | 85.74 | <0.001 | |
| G | 14 | 21 | |||||
| TLR4 Thr399Ile | CC | 75 | 10 | 1 | - | - | R |
| CT | 20 | 13 | 4.57 | 1.02 | 20.34 | 0.046 | |
| TT | 5 | 2 | 2.28 | 0.124 | 41.98 | 0.577 | |
| C | 170 | 33 | 2.727 | 0.869 | 8.55 | 0.04 | |
| T | 30 | 17 | |||||
| TLR4 Asp299Gly | AA | 85 | 11 | 1 | - | - | R |
| AG | 10 | 2 | 10.28 | 1.73 | 60.9 | 0.01 | |
| GG | 5 | 7 | 2.57 | 0.14 | 47.01 | 0.524 | |
| A | 180 | 25 | 4.318 | 1.209 | 15.42 | 0.024 | |
| G | 20 | 15 | |||||
CI, Confidence interval; OR, odds ratio