Figure 7.

Summary schematic of the BBSome subcomplexes and their localization in photoreceptor cilia in BBS mouse models. (a) The BBSome1·5·8·9 subcomplex localizes to photoreceptor cilia in Bbs2^−/− and Bbs7^−/− mice. These mice have comparatively mild retinal degeneration. (b) The BBSome1·2·5·7·9 subcomplex is denied ciliary entry in photoreceptor cells in Bbs8^−/− mice. These mice have more severe retinal degeneration compared with that in Bbs2^−/− and Bbs7^−/− mice. (c) The entire BBSome is present in photoreceptor cilia in Bbs3^−/− mice. These mice have the most severe retinal degeneration. These observations are listed in (d).