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. 2021 Mar 26;12:653209. doi: 10.3389/fgene.2021.653209

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Copyright © 2021 He, Liu, Li, Zhuang, Dai, Wang and Bi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the topological properties and functional modules of the PPI network of DEGs and crosstalk genes. (A) This picture represents the protein interaction network of two series of integrated DEGs. There are 647 relationship pairs and 515 nodes in the network. (B) This picture is a moderate topological analysis of the PPI network of DEGs and the five functional modules in the network. (C) This picture shows the PPI network of crosstalk gene, which has 58 relational pairs and 57 nodes. (D) This picture is the three modules in the PPI network of crosstalk gene. (E) Bar graph of enriched terms across TF and target genes associated with immune pathways, colored by p-values. (F) Network of enriched terms colored by cluster ID, where nodes that share the same cluster ID are typically close to each other.