Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar;9(5):422. doi: 10.21037/atm-20-5162

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

PMC Copyright notice

The classical necroptosis signaling pathway initiated by the combining of TNF ligand and TNF receptor 1. The combination of TNF α and TNF receptor 1 can induce necroptosis, when the caspase-8 activity is inhibited. The binding between RIP1, RIP3 and MLKL induces the phosphorylation of MLKL and subsequent execution of necroptosis. In addition, IFNs also trigger necroptosis independently of RIPK1 via the interferon-induced protein kinase PKR. Toll receptor and DAI can activate RIPK3 independent of RIPK1.