Table 5. Changes of Functional connectivity network of two-status (Nocebo-Pain) comparison in the extrovert group.

	ACC	CPL	PHPl	PHPr	AMYG	OFC	MTLl	AG	MTLr	DLPFC	pgACC	PCC	PFC	MCC	S1
ACC	N/A	‒0.1868*	‒0.2652*	‒0.1544*	0.1379	0.3276*	‒0.1804	0.2347*	0.2019*	0.3599*	0.1722	‒0.2111*	0.3089	‒0.1280	0.2474*
CPL	‒0.1868*	N/A	‒0.1348	0.0546	0.0199	‒0.0530	‒0.0737	‒0.0019	‒0.0241	‒0.0318	0.0528	0.0080	‒0.0145	‒0.0142	‒0.1598*
PHPl	‒0.2652*	‒0.1348	N/A	0.0330	‒0.0094	‒0.1286*	0.0301	0.0098	0.0419	‒0.0564	0.0119	0.0713	0.1127	‒0.0614	0.0573
PHPr	‒0.1544*	0.0546	0.0330	N/A	‒0.0812	0.0064	0.2023*	‒0.1440*	‒0.2231*	‒0.1562*	‒0.0539	0.0838	‒0.1884*	‒0.0163	0.0484
AMYG	0.1379	0.0199	‒0.0094	‒0.0812	N/A	0.1159	‒0.0551	‒0.0067	‒0.0928	‒0.1115	0.1367*	‒0.0048	0.1068	0.0120	0.0206
OFC	0.3276*	‒0.0530	‒0.1286*	0.0064	0.1159	N/A	‒0.1483	0.1437*	0.0538	0.2529*	‒0.0074	‒0.0003	‒0.0397	‒0.1007	0.0001
MTLl	‒0.1804	‒0.0737	0.0301	0.2023*	‒0.0551	‒0.1483	N/A	0.0263	‒0.0759	0.0056	‒0.1075	‒0.0370	‒0.0071	‒0.0638	0.0212
AG	0.2347*	‒0.0019	0.0098	‒0.1440*	‒0.0067	0.1437*	0.0263	N/A	‒0.0422	0.1118	0.0422	0.0130	0.0522	‒0.0127	‒0.0113
MTLr	0.2019*	‒0.0241	0.0419	‒0.2231*	‒0.0928	0.0538	‒0.0759	‒0.0422	N/A	‒0.0118	‒0.0685	0.0341	0.1073	0.0085	0.1036
DLPFC	0.3599*	‒0.0318	‒0.0564	‒0.1562*	‒0.1115	0.2529*	0.0056	0.1118	‒0.0118	N/A	0.0485	0.0479	‒0.0969	0.0836	‒0.0247
pgACC	0.1722	0.0528	0.0119	‒0.0539	0.1367*	‒0.0074	‒0.1075	0.0422	‒0.0685	0.0485	N/A	0.0495	‒0.0209	0.0456	0.0048
PCC	‒0.2111*	0.0080	0.0713	0.0838	‒0.0048	‒0.0003	‒0.0370	0.0130	0.0341	0.0479	0.0495	N/A	‒0.1657	‒0.1533	‒0.1110
PFC	0.3089	‒0.0145	0.1127	‒0.1884*	0.1068	‒0.0397	‒0.0071	0.0522	0.1073	‒0.0969	‒0.0209	‒0.1657	N/A	0.0578	‒0.1136
MCC	‒0.1280	‒0.0142	‒0.0614	‒0.0163	0.0120	‒0.1007	‒0.0638	‒0.0127	0.0085	0.0836	0.0456	‒0.1533	0.0578	N/A	0.0886
S1	0.2474*	‒0.1598*	0.0573	0.0484	0.0206	0.0001	0.0212	‒0.0113	0.1036	‒0.0247	0.0048	‒0.1110	‒0.1136	0.0886	N/A

The values presented in the table represent mean functional connectivity strength with prediction going from row to column. *, the group means are significantly different between the nocebo response and the pain status, where a within-group effect was also present in the placebo response (two-tailed tests; all P<0.05). ACC, anterior cingulate cortex; AG, angular gyrus; AMYG, amygdala; CPL, cerebellum posterior lobe; DLPFC, dorsolateral prefrontal cortex; MCC, mid-cingulate cortex; MTL, middle temporal lobe; OFC, orbitofrontal cortex; PFC, prefrontal cortex; pgACC, pregenual anterior cingulate cortex; PCC, posterior cingulate cortex; PHP, parahippocampal gyrus; S1, primary somatosensory area.