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. 2021 Mar;9(5):394. doi: 10.21037/atm-20-6456

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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miR-196b-5p was highly expressed in HemSCs-exos and IH tissues. (A) The volcano plot depicted the differentially expressed miRNAs in HemSCs-exos and HUVECs-exos. The up-regulated and down-regulated miRNAs in HemSCs-exos reaching a significance level of corrected P<0.05 and a fold change > 1.5 were selected. (B) Differentially expressed miRNAs ranked by TPM values were shown in the heatmap. (C) qRT-PCR detected that the expression level of miRNAs in IH tissues. Among 6 miRNAs, miR-196b-5p was the most abundantly expressed miRNA. (D) qRT-PCR showed the expression level of miR-196b-5p in HemSCs-exos and HUVECs-exos. All experiments were repeated at least 3 times independently. Results are shown as mean ± standard deviation. *P<0.05.