TABLE 2.
Functional annotation of relevance to neurogranin‐correlated/co‐expressed gene in Alzheimer's disease
| GeneSet | Size | System | Gene category | Overlap | GeneSet | Popoverlap | Pop | FET_P | Corr_P | Fold_Enrich |
|---|---|---|---|---|---|---|---|---|---|---|
| Positive | 226 | Bio Pro | Transmission of nerve impulse | 30 | 201 | 440 | 13178 | 4.82E‐12 | 4.80E‐08 | 4.470149254 |
| Positive | 226 | Bio Pro | Synaptic transmission | 27 | 201 | 415 | 13178 | 1.80E‐10 | 1.80E‐06 | 4.265491818 |
| Positive | 226 | Bio Pro | Cell–cell signaling | 35 | 201 | 906 | 13178 | 2.90E‐07 | 0.0029 | 2.532755648 |
| Positive | 226 | Mol Fun | Potassium channel activity | 12 | 201 | 133 | 13178 | 8.72E‐07 | 0.0086 | 5.915385479 |
| Positive | 226 | Cell Com | Vol‐gated potassium channel complex | 10 | 201 | 88 | 13178 | 8.75E‐07 | 0.0087 | 7.450248756 |
| Positive | 226 | Bio Pro | Potassium ion transport | 13 | 201 | 174 | 13178 | 2.60E‐06 | 0.026 | 4.89832447 |
| Positive | 226 | Bio Pro | Neuron development | 14 | 201 | 205 | 13178 | 3.08E‐06 | 0.031 | 4.477417789 |
| Negative | 37 | Bio Pro | Sister chromatid cohesion | 3 | 33 | 12 | 13178 | 3.10E‐06 | 0.031 | 99.83333333 |
| Positive | 226 | Bio Pro | Neuron differentiation | 17 | 201 | 299 | 13178 | 3.31E‐06 | 0.033 | 3.7276161 |
| Positive | 226 | Mol Fun | Vol‐gated potassium channel activity | 10 | 201 | 104 | 13178 | 4.09E‐06 | 0.041 | 6.30405664 |
| Positive | 226 | Mol Fun | Cation channel activity | 16 | 201 | 273 | 13178 | 4.41E‐06 | 0.044 | 3.82472619 |
Abbreviations: FET_P, Fisher exact test P value; Corr_P, BH‐corrected P value.