Representative clinical pictures of the collodion-baby phenotype (A), lamellar ichthyosis/LI (B), congenital ichthyosis erythroderma/CIE (C), epidermolytic ichthyosis/EI (D), and Netherton syndrome/NS (E-F). They share varying degrees of erythema and scaling, as in two common inflammatory skin diseases, atopic dermatitis/AD (G) and psoriasis (H). (I-M) Clinical severity scores by subtypes of ichthyosis. +p<0.1, *p<0.05, **p<0.01.