Table 1.
Patient demographics and clinical severity scores.
| A. Characteristics of subjects with different ichthyosis subtypes. | ||||||
|---|---|---|---|---|---|---|
| Characteristic | Parameter | CIE (n = 6) | LI (n = 7) | EI (n = 5) | NS (n = 3) | P-value |
| Age (years) | Mean (±SD) | 26.4 ± 14.7 | 30.4 ± 14.8 | 27.6 ± 19.2 | 18.2 ± 5.3 | 0.718 |
| Median [age range] | 23.2 [10.8 – 45] | 28.0 [10.8 – 57] | 17.9 [11.6 – 55] | 19.2 [12.5 – 23] | ||
| Gender | Female | 3 | 6 | 3 | 1 | 0.511 |
| Male | 3 | 1 | 2 | 2 | ||
| Race | White | 5 | 5 | 5 | 2 | 0.695 |
| Black | 0 | 1 | 0 | 1 | ||
| Asian | 1 | 0 | 0 | 0 | ||
| Hispanic | 0 | 1 | 0 | 0 | ||
| Disease Severity Scores | IASI (±SD) | 24.5 ± 11.1 | 29.7 ± 8.0 | 33.6 ± 6.3 | 27.3 ± 12.3 | 0.437 |
| IASI-E (±SD) | 13.9 ± 8.9 | 10.3 ± 6.4 | 15.1 ± 6.7 | 16.2 ± 11.0 | 0.652 | |
| IASI-S (±SD) | 10.6 ± 4.7 | 19.4 ± 5.5 | 18.5 ± 4.9 | 11.1 ± 1.3 | 0.017 | |
| TEWL (g/m2/hr, ±SD) | 22.1 ± 5.4 | 16.2 ± 4.5 | 15.2 ± 6.8 | 28.1 ± 0.0 | 0.04 | |
| 5-D Itch Scale (±SD) | 11.2 ± 3.1 | 13.8 ± 5.8 | 10.2 ± 3.1 | 17.0 ± 7.1 | 0.268 | |
AD: atopic dermatitis; CIE: congenital ichthyosiform erythroderma; EI: erythrodermic ichthyosis; NS: Netherton syndrome; IASI: ichthyosis area severity index (with E: erythema; S: scaling); LI: lamellar ichthyosis; LS: lesionai; N/A: not applicable. NL: non- lesional; PASI: psoriasis area severity index; PSO: psoriasis; SCORAD: scoring atopic dermatitis; SD: standard deviation; TEWL: transepidermal water loss.