Table 2.
Comparison of ichthyosis patients vs. healthy controls and subjects with AD or psoriasis.
| Comparison of ichthyosis patients vs. healthy controls and subjects with AD or psoriasis. | |||||||
|---|---|---|---|---|---|---|---|
| Characteristic | Parameter | Controls (n=16) | Ichthyosis (n=21; LS=21) | P-value Controls vs. Ichthyosis | AD (n=16; LS=16; NL=16) | PSO (n=10; LS=10; NL=10) | P-value All groups |
| Age (years) | Mean (±SD) | 38.7 ± 17.1 | 26.8 ± 14.6 | 0.033 | 52.8 ± 13.1 | 51.3 ± 11.0 | < 0.001 |
| Median [age range] | 44.5 [10.6–57] | 23.0 [10.8–57] | 49.5 [33–73] | 54.0 [30–64] | |||
| Gender | Female | 7 | 13 | 0.444 | 8 | 4 | 0.609 |
| Male | 9 | 8 | 8 | 6 | |||
| Race | White | 13 | 17 | 0.269 | 16 | 10 | 0.201 |
| Black | 0 | 2 | 0 | 0 | |||
| Asian | 0 | 1 | 0 | 0 | |||
| Hispanic | 3 | 1 | 0 | 0 | |||
| Disease Severity Scores | IASI | SCORAD | PASI | ||||
| Mean (±SD) | N/A | 28.9 ± 9.0 | 56.6 ± 10.7 | 20.3 ± 15.4 | |||
| Median [IQR] | N/A | 29.7 [21.2 – 36.0] | 55.0 [51.5 – 63.0] | 14.2 [12.1 – 21.2] | |||
AD: atopic dermatitis; CIE: congenital ichthyosiform erythroderma; EI: erythrodermic ichthyosis; NS: Netherton syndrome; IASI: ichthyosis area severity index (with E: erythema; S: scaling); LI: lamellar ichthyosis; LS: lesionai; N/A: not applicable. NL: non- lesional; PASI: psoriasis area severity index; PSO: psoriasis; SCORAD: scoring atopic dermatitis; SD: standard deviation; TEWL: transepidermal water loss.