Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 22;44(4):zsaa286. doi: 10.1093/sleep/zsaa286

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

PMC Copyright notice

Figure 7. — Statin reduces IH-induced endothelial vWF and angiopoietin-2 release. (A) Representative confocal images of intracellular vWF protein expression in HUVECs after stimulation with recombinant C9 and treatment with atorvastatin or vehicle in normoxia and IH. EC plasma membrane is identified by immunofluorescence for VE–cadherin. Scale bars: 20 μm. (B) Quantitation of intracellular vWF protein expression (fluorescence area in μm²) in HUVECs after stimulation with C9 and treatment with atorvastatin or vehicle in normoxia and IH (n = 4). (C) Quantitation of vWF levels in HUVECs culture media in normoxia and IH after stimulation with C9 and treatment with atorvastatin or vehicle (n = 6). (D) Representative histogram with a log scale x-axis and quantification of vWF fluorescence intensity on the cell surface in HUVECs in normoxia (n = 7) and IH (n = 8) after stimulation with C9 and treatment with vehicle. (E) Representative histogram with a log scale x-axis and quantification of vWF fluorescence intensity on the cell surface in HUVECs in normoxia (n = 7) and IH (n = 8) after stimulation with C9 and treatment with atorvastatin. (F) Quantitation of angiopoietin-2 levels in HUVECs culture media in normoxia and IH after stimulation with C9 and treatment with atorvastatin or vehicle expressed in ng/mL (n = 6). All data throughout the figure are shown as the mean ± SE, two-sided t-test test. Abbreviations as in Figure 2.