Table 2:

Factors associated with the presence of lamina propria and lamina propria fibrosis in esophageal biopsies obtained from children with and without EoE

Category	Factors	Presence of lamina propria (N=217)				Factors	Presence of lamina propria fibrosis (N=123)
		OR (95% CI)	P value	aOR (95% CI)	P value		OR (95% CI)	P value	aOR (95% CI)	P value
Demographics	Male	3.11 (1.74–5.54)	<0.001			Male	6.51 (1.46–29.02)	0.01	8.37 (1.23–56.74)	0.03
	Age	0.89 (0.83–0.95)	0.001
Clinical	Antihistamines	2.13 (1.21–3.73)	0.008			Allergic rhinitis	2.29 (1.02–5.14)	0.04
	Nasal topical steroids	3.03 (1.62–5.66)	0.001			Asthma	2.35 (1.03–5.35)	0.04
	Abdominal pain	0.36 (0.20–0.64)	0.001			Dysphagia	3.18 (1.22–8.25)	0.01
Endoscopy	Edema	3.58 (1.68–7.62)	0.001			Edema	6.44 (2.68–15.45)	<0.001
	Furrows	3.93 (1.94–7.94)	<0.001			Exudates	4.54 (1.71–12.03)	0.002
	EREFS	1.88 (1.34–2.63)	<0.001			Furrows	4.90 (2.06–11.64)	<0.001
						EREFS	2.00 (1.43–2.79)	<0.001
Histology	Number of biopsies	1.25 (1.07–1.46)	0.004			Number of biopsies	1.39 (1.10–1.75)	0.005
	PEC	1.02 (1.01–1.03)	<0.001			PEC	1.03 (1.01–1.04)	<0.001	1.02 (1.00–1.04)	0.01
Activity	Active EoE	4.47 (1.88-10.63)	0.001	4.23 (1.00-18.13)	0.05	Active EoE	6.68 (1.82-24.44)	0.004

OR: Odds ratio; aOR: adjusted odds ratio; CI: confidence interval; EREFS: endoscopic reference score; PEC: peak eosinophil counts