Skip to main content
. 2021 Mar 10;13(4):e13328. doi: 10.15252/emmm.202013328

Figure 1. Overview of the experiments and observational study presented in this article.

Figure 1

  1. The first mouse experiment performed at LUMC was set up to compare gene expression profiles of healthy (WT) and dystrophic (mdx, mdx++ and mdx+−) mice. It involved 40 mice and resulted in the collection of two datasets, one with cross‐sectional RNA‐sequencing in muscle (MoMus) and the other with longitudinal RNA‐sequencing measurements in blood (MoLong).
  2. The second mouse experiment performed at LUMC aimed to assess the effect of dystrophin restoration by two antisense oligonucleotides (PMO and PS49) on blood gene expression. It involved 15 dystrophic mice and led to the generation of a cross‐sectional dataset (MoTreat) with blood RNA‐sequencing data.
  3. The observational study carried out at SMDM involved 18 healthy subjects and 39 DMD patients. It resulted in the collection of a cross‐sectional dataset (DMDMex) with blood RNA‐sequencing data.