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. Author manuscript; available in PMC: 2021 Jun 18.
Published in final edited form as: Mol Cell. 2020 May 13;78(6):1086–1095. doi: 10.1016/j.molcel.2020.04.023

Figure 1. PROTACs bridge a target protein of interest and an E3 ligase complex to induce selective degradation.

Figure 1.

By the PROTAC strategy, a chemical structure bridging a target protein of interest (red) and the substrate receptor of an E3 ubiquitin ligase containing complex (green) results in E2-dependent ubiquitination of the target protein. This leads to recruitment of the target protein to the proteasome and proteasomal degradation. Differences between CRBN and VHL-based PROTAC complexes are demonstrated.