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. Author manuscript; available in PMC: 2021 Apr 9.
Published in final edited form as: J Pathol. 2018 Dec 27;247(2):166–176. doi: 10.1002/path.5176

Figure 2. Recurrent somatic mutations in TP53, H3F3A, ATRX and DOT1L.

Figure 2.

All the mutations (black balls) are missenses except for one an in-frame insertion in H3F3A. The relative positions of mutations are shown in the predicted protein sequence of (A) TP53, (B) H3F3A, (C) ATRX and (D) DOT1L. T.A.: p53 transactivation domain; T.M.: p53 tetramerization domain; ADD: ATRX-DNMT3-DNMT3L domain; EZH2: enhancer zeste homologue 2 protein (EZH2) interacting region; DAXX: death domain-associated protein interacting domain; ATPase: Helicase adenosine triphosphatase domain; Catalytic DOT1 domain: Histone-lysine N-methyltransferase DOT1 domain; STAT1: signal transducer and activator of transcription 1 binding motifs.