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. 2021 Feb 12;4(2):730–743. doi: 10.1021/acsptsci.0c00201

Figure 4.

Figure 4

Induction of γH2AX by CHK1i. (A) ASPC-1 cells were incubated with the indicated concentrations of MK-8776 for 6 h and then analyzed by flow cytometry for DNA content, γH2AX, and pHH3. The percentage of cells positive for γH2AX or pHH3 is indicated. The percentage of γH2AX-positive cells from replicate experiments is presented. (B) MDA-MB-231, SW620, and H322M cells were incubated with the indicated concentrations of each CHK1i for 6 or 24 h and analyzed as in panel A. The flow cytometry data for these analyses are presented in Figure S1.